Video: Click hereAbstractScutellaria barbata (SB), a Chinese medical herb, has been known to contain anti-cancer properties. In this study, the effectiveness of SB in apoptotic modulation of APC-mutant breast cancer cell lines MDA-MB-157, 93A, and 93B were investigated. Assessments were performed using the green/red/blue fluorescent Apoptosis/Necrosis Detection Kit and the Human Apoptosis Antibody Array -Membrane (43 Targets) test by
the Abcam cooperation. Our data demonstrated that 1-hour and 3-hour incubation treatments with aqueous extract of SB induced apoptosis in all cell lines. Additionally, modulation of pro-apoptotic markers (Bad,
Bax, BID, BIM, C3, C8, p53, p27), and anti-apoptotic markers (BcL-2, Bcl-w, p21) were observed.
Poster:
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